斑疹伤寒立克次氏体IgG ELISA试剂盒

斑疹伤寒立克次氏体IgG ELISA试剂盒

Rickettsia prowazekii IgG ELISA Kit

广州健仑生物科技有限公司

主要用途：用于检测人血清中的斑疹伤寒立克次氏体 IgG 抗体

产品规格：96人份/盒

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斑疹伤寒立克次氏体IgG ELISA试剂盒

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

霍华德·休斯医学研究所的研究员Nudler说，他的团队的研究表明，eEF1A1通过招募一个关键转录因子对热休克基因激活转录。它也稳定了HSP的mRNA，并帮助这些RNA转出细胞核并将它们传递到细胞的核糖体中用于蛋白质的合成。Nudler说，以这种方式，eEF1A1掌管了响应于应力制造HSP的整个过程。然后HSP结合到其他的蛋白质中，阻止其毒性聚集。
该eEF1A蛋白在不同的组织中被表达为两个类似的形式，1和2。Nudler及其同事表明，例如，运动神经元表达形式2(eEF1A2)，其不支持热休克反应。他们认为，这就是为什么这些特殊细胞无法安装热休克反应的原因，因此这些运动神经元特别容易受到压力和疾病，如ALS。在药物开发所面临的挑战将是通过调节eEF1A的活性恢复运动神经元的热休克反应。
Nudler实验室在这项研究中使用的是各种人类和小鼠细胞系。
人一旦通过练习掌握了一个动作，之后就能简单重复了。这说明大脑拥有运动学习功能，能形成新的运动记忆。日本研究人员日前报告说，他们在大脑皮质运动区发现了与运动记忆有关的脑活动的形成机制。
高知工科大学等机构的研究人员在新一期美国《神经科学杂志》上发表了他们的研究成果。在实验中，研究人员让受试者用手抓住机器人的机械臂，将屏幕上的光标从开始点笔直地移动到目的地，此外还通过机械臂对受试者施加外部干扰，然后利用经颅磁刺激技术观察受试者大脑皮质运动区的活动发生了何种变化。

Nudler, a Howard Hughes Medical Institute researcher, said his team's latest study shows that eEF1A1 activates transcription by activating a critical transcription factor on heat shock genes. It also stabilizes HSP mRNA and helps to transfer these RNAs out of the nucleus and deliver them to the cell's ribosomes for protein synthesis. In this way, Nudler said, eEF1A1 is in charge of the entire process of making HSPs in response to stress. The HSP then binds to other proteins, preventing its toxic build-up.
The eEF1A protein is expressed in two different forms, 1 and 2, in different tissues. Nudler and colleagues show that, for example, motor neuron expression 2 (eEF1A2), which does not support the heat shock response. This is why they think these special cells are unable to install the heat shock response, they think, and are therefore particularly vulnerable to stress and disease such as ALS. The challenge in drug development will be to restore the heat shock response of motor neurons by modulating the activity of eEFlA.
Nudler Laboratories used a variety of human and mouse cell lines in this study.
Once a person masters an action through practice, it can be simply repeated. This shows that the brain has a motor learning function, can form a new memory. Japanese researchers recently reported that they found a mechanism for the formation of motor activity associated with motor memory in the motor cortex.
Researchers at institutions such as Kochi University of Technology published their findings in a new issue of the Journal of Neuroscience. In the experiment, the researcher allowed the subject to grab the robotic arm with his hand, move the cursor on the screen straight from the starting point to the destination, and additionally subject the subject to external disturbances through the robotic arm, Cranial magnetic stimulation technique was used to observe changes in the activity of the motor cortex in the subject.