The autumn of November 3, 2017 is the best time to hold group events and strengthen the cohesion of the company. Guangzhou Jianlun Biotechnology Co., Ltd. upholds the concepts and attitudes of solidarity, fraternity, mutual aid, dedication, collaboration, and innovation. To improve the physical fitness of employees and strengthen corporate culture, it actively participates in the Games organized by this Science Park.

At 2 o'clock in the afternoon, in the sun, in the song, on the field, the first fun games of Panyu Innovation and Technology Park kicked off! With the high voice of the host, the crowds on the court lined up in neat rows. The team leader stood in the front of the team holding up the signs of each representative team. The participating athletes were eagerly arranged in the ranks and waiting for the start of the sports meeting. Then, the leader of the Science Park and the leader of the Guangzhou Mountaineering Association made a speech and wished the Games a success!

After the opening ceremony, under the leadership of the host, the athletes completed the warm-up exercise. The upcoming game is a rousing game. The company's first competition program is to test the coordination of the body and teamwork thunderbolt. As the whistle sounded, six colleagues carefully waved the balloons on the drums with a concerted pace and rhythm. The two colleagues were waiting for their help and were ready to pick up the flunging balloons. With nervousness and excitement, every colleague is working hard to complete the game. With the sound of the referee's ending, colleagues were relaxed, but due to lack of exercise, our performance on this project was not satisfactory. The company’s leader, Zhan Zhan, encouraged everyone at this time to cheer up morale and achieved better results in the next game.

At three o'clock in the afternoon, the colleagues of Jianlun Biology were engaged in a penalties game. Accompanied by cheers, I saw my colleagues kick one exciting goal after another and the score went up. In the end, Jianlun Bios achieved good results in the top five on this project. During the intermission, Zhan summoned everyone to a brief summary and encouraged everyone to continue their efforts to achieve better performance. Sure enough, in the following tortoise-bitch races and super-shooting sessions, colleagues performed better and better, demonstrating the positive appearance of Jianlun Biocorp. and the corporate culture of solidarity and cooperation.

At five o'clock in the afternoon, as the last athlete crossed the finish line, the game also came to a close. In the next award ceremony, the winning teams and athletes received commendation and prizes. The sports event was over, but the success and spirit gained through the games will continue to circulate, and it will become a shining landscape on the path of Guangzhou Jianlun Biosciences!

努力，我们一直在路上，明天会更好！

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【公司名称】广州健仑生物科技有限公司

【市场部】杨永汉
【】
【腾讯】
【公司地址】广州市清华科技园健新基地番禺石楼镇健启路63号二期2幢101-103室

三条前α链的C端前肽借二硫键形成链间交联，使三条前α链“对齐”排列。然后从C端向N端形成三股螺旋结构。前肽部分则呈非螺旋卷曲。带有前肽的三股螺旋胶原分子称为前胶原（ procollgen）。胶原变性后不能自然复性重新形成三股螺旋结构，原因是成熟胶原分子的肽链不含前肽，故而不能再进行“对齐” 排列。前α链在粗面内质网上合成，并在形成三股螺旋之前于脯氨酸及赖氨酸残基上进行羟基化修饰，脯氨酸残基的羟化反应是在与膜结合的脯氨酰-羟化酶及脯氨酰-羟化酶的催化下进行的。维生素C是这两种酶所必需的辅助因子。维生素C缺乏导致胶原的羟化反应不能充分进行，不能形成正常的胶原原纤维，结果非羟化的前α链在细胞内被降解。因而，膳食中缺乏维生素C可导致血管、肌腱、皮肤变脆，易出血，称为坏血病。胶原（collgen）是细胞外基质的zui重要成分，目前已发现至少型胶原，但肝脏中含量较高者仅包括Ⅰ、Ⅲ、Ⅳ、Ⅴ、Ⅵ、Ⅹ和 Ⅷ型。
The C-terminal propeptides of the three pre-alpha chains are disulfide-bonded to form interchain crosslinks, aligning the three pre-alpha chains. Then three helix structures are formed from the C-terminus to the N-terminus. The propeptide portion is non-coiled. The triple helical collagen molecule with the propeptide is called procollagen. After collagen denaturation, the three-stranded helix structure cannot be reformed naturally. The reason is that the peptide chain of the mature collagen molecule does not contain the pre-peptide, so it cannot be “aligned”. The pre-alpha chain was synthesized on the rough endoplasmic reticulum and hydroxylated on valine and lysine residues before the triple helix was formed. The hydroxylation of the proline residue was in the membrane-bound hydrazine. Acyl-hydroxylases and prolyl-hydroxylases are catalyzed. Vitamin C is a necessary cofactor for these two enzymes. The lack of vitamin C causes the hydroxylation of the collagen to fail to fully proceed and does not form normal collagen fibrils. As a result, the non-hydroxylated prealpha chain is degraded within the cell. Thus, the lack of vitamin C in the diet can cause blood vessels, tendons and skin to become brittle and easily bleed, called scurvy. Collagen (collgen) is the most important component of the extracellular matrix, and at least collagen has been found, but the higher levels in the liver include only type I, III, IV, V, VI, X, and VIII.

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